Royal Air Force Typhoon fighter aircraft have joined forces with France's air force in a combined operation on an underground arms cache in Syrian territory operated by the IS group, according to the UK's MoD.
The facility, located using intelligence, was thought to be storing arms and explosives, the announcement noted, and was positioned in mountainous terrain just above Palmyra in Syria's central region.
"The RAF jets used laser-guided Paveway IV weapons to hit a number of entry passages leading to the site... early reports suggest the target was engaged successfully," the MoD said.
There was no sign of any harm to civilians in the attack late on Saturday and each participating jet returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager refuelling tanker.
IS - referred to as Daesh - imposed militant control over large swathes of Iraq and Syria until 2019.
"This strike demonstrates our UK leadership, and commitment to work closely with our allies, to stamp out any re-emergence of IS and their violent and radical beliefs in the area," Britain's Defence Chief the minister stated.
UK warplanes have carried out surveillance missions over Syrian airspace to "deter any efforts to regroup" of Islamic State following its routing at the battle of Baghuz in the year 2019, the MoD reported.
"I must thank the personnel of British forces participating in this mission for their skill and their bravery," Healey said. "They were among a great many UK service members stationed over Christmas and New Year. This operation, to remove dangerous terrorists who pose a risk to our safety, shows how our armed forces are always on standby, all year round, protecting the UK domestically and strong abroad."
During December, the United States armed forces executed what it termed a "massive strike" on Islamic State objectives in the country, following an assault claimed the lives of two US troops and a local interpreter in the Palmyra area.
The UN says Daesh still boasts an estimated 5,000 to 7,000 fighters in Syria and Iraq.